|
| Character: | Actor: | Notes: |
| Captain / President John J. Sheridan | Bruce Boxleitner | Seasons 2-5 plus In The Beginning + Thirdspace + Call To Arms |
| Commander Susan Ivanova | Claudia Christian | Seasons 1-4 plus ep Sleeping In Light +In The Beginning + Thirdspace |
| Ambassador Delenn | Mira Furlan | Seasons 1-5 |
| Security Chief Michael Garibaldi | Jerry Doyle | Seasons 1-5 |
| Ambassador Londo Mollari | Peter Jurasik | Seasons 1-5 |
| Dr. Stephen Franklin | Richard Biggs | Seasons 1-5 |
| Ambassador G'Kar | Andreas Katsulas | Seasons 1-5 |
| Lennier | Bill Mumy | Seasons 1-5 |
| Commander Jeffrey Sinclair / Valen | Michael O' Hare | Season 1 +ep Coming of Shadows |
| Zack Allen | Jeff Conaway | Seasons 2-5 plus; Thirdspace +River of Souls +A Call to Arms |
| Mr Morden | Ed Wasser | Season 1-4 |
| Lyta Alexander | Patricia Tallman | Season 1-5 |
| Talia Winters | Andrea Thompson | Season 1-3 |
| Captain Elizabeth Lochley | Tracy Scoggins | Season 5 +River of Souls +A Call to Arms |
| Notable Guest Stars: | ||
| Dr. Vance Hendricks | David McCallum | Infection |
| PSI Cop Alfred Bester | Walter Koenig | Frequent appearances seasons 1-5 |
| Harriman Gray | Jeffrey Combs | Eyes |
| Amis | Dwight Schultz | The Long Dark |
| Brother Edward | Brad Dourif | Passing Through Gethsemane |
| Jeremiah | Robert Englund | Grey 17 is Missing |
|
|